The effects of non-steroidal inhibitors of phospholipase Az on leukotriene and histamine release from human and guinea-pig lung
Identifieur interne : 003455 ( Main/Exploration ); précédent : 003454; suivant : 003456The effects of non-steroidal inhibitors of phospholipase Az on leukotriene and histamine release from human and guinea-pig lung
Auteurs : J. G. Kench [Australie] ; J. P. Seale [Australie] ; D. M. Temple [Australie] ; C. Tennant [Australie]Source :
- Prostaglandins [ 0090-6980 ] ; 1985.
Descripteurs français
- KwdFr :
- A-23187 (pharmacologie), Animaux, Chloroquine (pharmacologie), Cochons d'Inde, Humains, Libération d'histamine (), Mépacrine (pharmacologie), Ovalbumine (immunologie), Phospholipases (antagonistes et inhibiteurs), Phospholipases A (antagonistes et inhibiteurs), Phospholipases A2, Poumon (), Poumon (métabolisme), Substances à réaction différée de l'anaphylaxie (métabolisme).
- MESH :
- antagonistes et inhibiteurs : Phospholipases, Phospholipases A.
- immunologie : Ovalbumine.
- métabolisme : Poumon, Substances à réaction différée de l'anaphylaxie.
- pharmacologie : A-23187, Chloroquine, Mépacrine.
- Animaux, Cochons d'Inde, Humains, Libération d'histamine, Phospholipases A2, Poumon.
English descriptors
- KwdEn :
- Animals, Calcimycin (pharmacology), Chloroquine (pharmacology), Guinea Pigs, Histamine Release (drug effects), Humans, Lung (drug effects), Lung (metabolism), Ovalbumin (immunology), Phospholipases (antagonists & inhibitors), Phospholipases A (antagonists & inhibitors), Phospholipases A2, Quinacrine (pharmacology), SRS-A (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Phospholipases, Phospholipases A.
- chemical , immunology : Ovalbumin.
- chemical , metabolism : SRS-A.
- chemical , pharmacology : Calcimycin, Chloroquine, Quinacrine.
- drug effects : Histamine Release, Lung.
- metabolism : Lung.
- Teeft :
- Animals, Arachidonic, Arachidonic acid, Calcium ionophore, Chloroquine, Control values, Guinea Pigs, Histamine, Histamine release, Human basophils, Human lung, Humans, Inhibitor, Inhibitory effects, Ionophore, Leukotriene, Leukotriene release, Lipoxygenase products, Lung fragments, Mepacrine, Other tissues, Perfused, Perfused lung, Pharmacol, Phospholipase, Phospholipases A2, Phospholipid, Prostaglandin, Total tissue histamine.
Abstract
Abstract: The effects of chloroquine and mepacrine were determined on the release of slow reacting substances (leukotrienes) from lung fragments in vitro. These drugs have been shown in a variety of tissues to inhibit phospholipase A2, and thus to reduce the availability of arachidonate, which is a substrate for leukotriene biosynthesis. Leukotriene and histamine release from unsensitized human lung was stimulated by calcium ionophore A23187, and from actively sensitized guinea-pig lung, by ovalbumin. Chloroquine (10 μM and 100 μM) significantly inhibited leukotriene release in lung from both species, and at 100 μM also inhibited histamine release. Mepacrine (10 μM) inhibited leukotriene release in human lung and at 100 μM in guinea-pig lung. The effects of chloroquine (100 μM) on leukotriene release were counteracted by the presence of arachidonic acid (10 μM), which suggests that chloroquine had impaired the availability of arachidonate. It seems probable that chloroquine and mepacrine inhibit leukotriene release by inhibition of phospholipase A2 in lung.
Url:
DOI: 10.1016/0090-6980(85)90185-6
Affiliations:
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Tennant</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pharmacology, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Prostaglandins</title><title level="j" type="abbrev">PROOLD</title><idno type="ISSN">0090-6980</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">30</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="199">199</biblScope><biblScope unit="page" to="208">208</biblScope></imprint><idno type="ISSN">0090-6980</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0090-6980</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Calcimycin (pharmacology)</term><term>Chloroquine (pharmacology)</term><term>Guinea Pigs</term><term>Histamine Release (drug effects)</term><term>Humans</term><term>Lung (drug effects)</term><term>Lung (metabolism)</term><term>Ovalbumin (immunology)</term><term>Phospholipases (antagonists & inhibitors)</term><term>Phospholipases A (antagonists & inhibitors)</term><term>Phospholipases A2</term><term>Quinacrine (pharmacology)</term><term>SRS-A (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>A-23187 (pharmacologie)</term><term>Animaux</term><term>Chloroquine (pharmacologie)</term><term>Cochons d'Inde</term><term>Humains</term><term>Libération d'histamine ()</term><term>Mépacrine (pharmacologie)</term><term>Ovalbumine (immunologie)</term><term>Phospholipases (antagonistes et inhibiteurs)</term><term>Phospholipases A (antagonistes et inhibiteurs)</term><term>Phospholipases A2</term><term>Poumon ()</term><term>Poumon (métabolisme)</term><term>Substances à réaction différée de l'anaphylaxie (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Phospholipases</term><term>Phospholipases A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Ovalbumin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>SRS-A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Calcimycin</term><term>Chloroquine</term><term>Quinacrine</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Phospholipases</term><term>Phospholipases A</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Histamine Release</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Ovalbumine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Poumon</term><term>Substances à réaction différée de l'anaphylaxie</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>A-23187</term><term>Chloroquine</term><term>Mépacrine</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Animals</term><term>Arachidonic</term><term>Arachidonic acid</term><term>Calcium ionophore</term><term>Chloroquine</term><term>Control values</term><term>Guinea Pigs</term><term>Histamine</term><term>Histamine release</term><term>Human basophils</term><term>Human lung</term><term>Humans</term><term>Inhibitor</term><term>Inhibitory effects</term><term>Ionophore</term><term>Leukotriene</term><term>Leukotriene release</term><term>Lipoxygenase products</term><term>Lung fragments</term><term>Mepacrine</term><term>Other tissues</term><term>Perfused</term><term>Perfused lung</term><term>Pharmacol</term><term>Phospholipase</term><term>Phospholipases A2</term><term>Phospholipid</term><term>Prostaglandin</term><term>Total tissue histamine</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cochons d'Inde</term><term>Humains</term><term>Libération d'histamine</term><term>Phospholipases A2</term><term>Poumon</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The effects of chloroquine and mepacrine were determined on the release of slow reacting substances (leukotrienes) from lung fragments in vitro. These drugs have been shown in a variety of tissues to inhibit phospholipase A2, and thus to reduce the availability of arachidonate, which is a substrate for leukotriene biosynthesis. Leukotriene and histamine release from unsensitized human lung was stimulated by calcium ionophore A23187, and from actively sensitized guinea-pig lung, by ovalbumin. Chloroquine (10 μM and 100 μM) significantly inhibited leukotriene release in lung from both species, and at 100 μM also inhibited histamine release. Mepacrine (10 μM) inhibited leukotriene release in human lung and at 100 μM in guinea-pig lung. The effects of chloroquine (100 μM) on leukotriene release were counteracted by the presence of arachidonic acid (10 μM), which suggests that chloroquine had impaired the availability of arachidonate. It seems probable that chloroquine and mepacrine inhibit leukotriene release by inhibition of phospholipase A2 in lung.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Nouvelle-Galles du Sud</li></region><settlement><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Kench, J G" sort="Kench, J G" uniqKey="Kench J" first="J. G." last="Kench">J. G. Kench</name></region><name sortKey="Seale, J P" sort="Seale, J P" uniqKey="Seale J" first="J. P." last="Seale">J. P. Seale</name><name sortKey="Temple, D M" sort="Temple, D M" uniqKey="Temple D" first="D. M." last="Temple">D. M. Temple</name><name sortKey="Tennant, C" sort="Tennant, C" uniqKey="Tennant C" first="C." last="Tennant">C. Tennant</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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